SPCDAnalyze: Design and Analyze Studies using the Sequential Parallel
Programs to find the sample size or power of studies using the
Sequential Parallel Comparison Design (SPCD) and programs to analyze
such studies. This is a clinical trial design where
patients initially on placebo who did not respond are re-randomized between
placebo and active drug in a second phase and the results of the two phases are
pooled. The method of analyzing binary data with this design is described in
Fava,Evins, Dorer and Schoenfeld(2003) <doi:10.1159/000069738>, and the
method of analyzing continuous data is described in Chen, Yang,
Hung and Wang (2011) <doi:10.1016/j.cct.2011.04.006>.
||nlme, lme4, plyr
||David A. Schoenfeld
||David A. Schoenfeld <dschoenfeld at mgh.harvard.edu>
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